e-mail : clara.sidor [at] univ-amu.fr
After studying Lifes sciences/Molecular and cellular Genetics in UPMC in Paris, I did my PhD in the team of Barry Thompson at the CRUK London Research Institute to work on the question of how developing organs reach their correct size. There, I identified and characterised a novel member of the Hippo growth signalling pathway. During that time, I developed an interest in how organ shapes arise during embryonic development by oriented tissue growth but also through coordinated morphogenetic changes. To explore this exciting topic, I joined the team of Katja Röper at the LMB in Cambridge as a PostDoc to work on a growth-independent morphogenetic system. This work identified a novel mechanism for creating tissue boundaries during development.
I am fascinated by developmental biology, and in particular by how apparently disordered systems can spontaneously organise to become ordered, and how patterns can emerge from simple mathematical and biophysical rules. One beautiful example of such an organisation process is the development of sarcomeres in muscle fibres, structures of almost crystalline regularity. The mechanism of this organisation is not yet understood. Using classical Drosophila genetics and advanced microscopy tools I am probing the genetic hierarchy and timeline of sarcomere assembly, aiming to identify key molecular events to understand this mechanism.
2020 – Researcher at CNRS, Muscle dynamics/Frank Schnorrer’s lab, Institut de Biologie du Développement de Marseille (IBDM)
2019-2020 Post-doctoral researcher (CENTURI), Muscle dynamics/Frank Schnorrer’s lab, Institut de Biologie du Développement de Marseille (IBDM), in collaboration with Dr Sophie Brasselet (Institut Fresnel)
2018-2019Post-doctoral researcher, Epithelial biology Laboratory/Barry Thompson’s lab, Francis Crick Institute (London)
2013-2018Post-doctoral researcher, Cell biology of dynamic epithelia during organ formation/Katja Röper’s lab, MRC Laboratory of Molecular Biology (Cambridge)
2007-2012PhD in Developmental Signaling, supervised by Barry Thompson/Epithelial Biology Laboratory, Cancer Research UK London Research Institute (CRUK LRI, now Francis Crick Institute), University College London (UCL)
2002-2007Bachelor in Life Sciences followed by Masters in Molecular and Cellular Genetics, Université Pierre et Marie Curie (UPMC, Paris 6) – Masters project with Stéphane Ronsseray, Institut Jacques Monod, and with Arnaud Echard, Institut Curie (Paris)
AFM-Téléthon Postdoctoral Fellowship
CENTURI Postdoctoral Fellowship
MRC Career Development Fellowship
CRUK PhD Studentship
Rho-kinase planar polarisation at tissue boundaries depends on phospho-regulation of membrane residence time. Sidor C.*, Stevens T., Boulanger J., Jin L., Röper K.* (*corresponding author) Developmental Cell 2020 Feb 10;52(3):364-378.e7
(Commented in: Dev cell 2020 Feb 10;52(3):255-256)
Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability.Sidor C1, Borreguero-Munoz N1, Fletcher GC1, Elbediwy A, Guillermin O, Thompson BJ. (1equal contribution), Elife. 2019 Oct29;8. pii: e48601.
Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination.Sidor CM, Röper K – Snapshot, Journal of Cell Biology 2017 May 1;216(5):1215-1218.
Genetic control of salivary gland tubulogenesis in Drosophila.Sidor CM, Röper K – 2016, Organogenetic Gene Networks Chapter 5 (p125-149), Springer International publishing
Mask proteins are cofactors of Yki/YAP in the Hippo pathway. Sidor CM, Brain R, Thompson BJ. Current Biology 2013 Feb 4;23(3):223-8. (Commented in: Nat Rev Mol Cell Biol. 2013 Apr;14(4):196)
Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila.Fichelson P, Moch C, Ivanovitch K, Martin C, Sidor CM, Lepesant JA, Bellaiche Y, Huynh JR. Nature Cell Biology 2009 Jun;11(6):685-93.
Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation.Josse T, Teysset L, Todeschini AL, Sidor CM, Anxolabéhère D, Ronsseray S. PLoS Genetics2007 Sep;3(9):1633-43.