Nuno Luis

CNRS Researcher and Marie Skłodowska-curie fellow

email: nuno.luis [at] univ-amu.fr

RESEARCH AND ACADEMIC EXPERIENCE

2016 – Postdoctoral Researcher at IBDM, Marseille, France. Marie Sklodowska-Curie Fellow. Dr. Frank Schnorrer Laboratory, Muscle Dynamics
2012 – 2016 – Postdoctoral Researcher at Buck Institute for Research on Aging, Novato, CA, USA. Hillblom Foundation for Medical Research Fellow. Dr. Pankaj Kapahi Laboratory, Nutrition and Metabolism in Lifespan and Disease
2007 – 2012 – PhD Student at CRG, Barcelona, Spain. Fundação para a Ciência e Tecnologia Fellow. Dr. Salvador Benitah Laboratory, Epithelial Homeostasis and Cancer
2006 – 2007 – Master Student at IMIM, Barcelona, Spain. Dr. Francisco X. Real Laboratory, Epithelial Carcinogenesis
2005 – Trainee at School of Pharmacy, London, U.K. Dr. Andy Wilderspin laboratory

PUBLICATIONS

Luis NM*, Wang L, Ortega M, Deng H, Katewa SD, Li PW, Karpac J, Jasper H*, Kapahi P* (2016) Intestinal IRE1 is required for increased triglyceride metabolism and longer lifespan under Dietary Restriction. Cell Reports 17, 1207-16. *co-corresponding authors.

Toufighi K, Yang JS, Luis NM, Benitah SA, Lehner B, Serrano L, Kiel C (2015) Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses. PLoS Comput Biol. 11, e1004256.

Janich P, Toufighi K, Solanas G, Luis NM, Minkwitz S, Serrano L, Lehner B, Benitah SA (2013) Human epidermal stem cell function is regulated by circadian oscillations. Cell Stem Cell 13, 745-53.

Ribeiro JD, Morey L, Mas A, Gutierrez A, Luis NM, Mejetta S, Richly H, Benitah SA, Keyes WM, Di Croce L (2013) ZRF1 controls oncogene-induced senescence through the INK4- ARF locus. Oncogene 32, 2161-8.

Luis NM, Morey L, Di Croce L, Benitah SA (2012) Polycomb in Stem Cells: PRC1 Branches Out. Cell Stem Cell 11, 16-21.

Luis NM, Morey L, Mejetta S, Pascual G, Janich P, Kuebler B, Cozutto L, Roma G, Nascimento E, Frye M, Di Croce L, Benitah SA (2011) Regulation of human epidermal stem cell proliferation and senescence requires polycomb-dependent and -independent functions of Cbx4. Cell Stem Cell 9, 233-46.

Hafner C*, López-Knowles E*, Luis NM*, Toll A, Baselga E, Fernández-Casado A, Hernández S, Ribé A, Mentzel T, Stoehr R Hofstaedter F, Landthaler M, Vogt T, Pujol RM, Hartmann A, Real FX (2007) Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc Natl Acad Sci U S A 104, 13450-4. (*co-authors)

Luis NM, Lopez-Knowles E & Real FX (2007) Molecular biology of bladder cancer. Clin Transl Oncol 9, 5-12

HONORS

Fellowships Awards
Marie Skłodowska-Curie Individual Fellowship
April 2017 to March 2019

Larry L. Hillblom Foundation for Medical Research
July 2013 to June 2016

Fundação para a Ciência e Tecnologia (Portugal)
September 2006 to August 2010

Prizes
2011 Sep – EMBO Best Prize Poster Presentation at the ”Stem Cells in Development and Disease” meeting at the Max Delbruck Center, Berlin, Germany

ACADEMIC DEGREES

PhD (Magna Cum Laude), Universitat Pompeu Fabra, Barcelona, Spain, Biomedicine (2011) 
Thesis Title: The Role of Cbx4/PC2 in Epidermal Stem Cell Homeostasis
MsC, Universitat Pompeu Fabra (UPF), Barcelona, Spain, Master in Biomedical Research (2007)
Thesis Title: Role of FGFR3 and PIK3CA oncogenic mutations in human neoplasms
BsC, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal, Applied Chemistry (5 year bachelor) (2005)
Classification: 16/20

SUMMARY

Nuno did his PhD at the lab of Dr Salvador Benitah studying epigenetic regulation of epidermal stem cells. His work presented evidence for multiple combinatorial arrangements of the PRC1 polycomb complex during different stages differentiation or maintenance of stemness.

He then pursued his interest in tissue homeostasis and loss of function with age and joined the group of Dr Pankaj Kapahi at the Buck Institute for Research on Aging, in the San Francisco Bay Area, USA. There he joined a field that was increasingly aware that different tissues mount tissue-specific responses to a dietary intervention shown to increase longevity and healthspan, called Dietary Restriction (DR). He then showed that IRE1, a mediator of the Endoplasmic Reticulum stress response, is required for the response to DR. During DR, a metabolic shift, from a glycolytic towards an oxidative metabolism takes place, which encompasses higher lipid turnover, and IRE1 is required for these initial stages. He now aims to utilize his expertise in mechanisms of tissue homeostasis and ageing to study maintenance of protein homeostasis in the muscle.